Assay Detail
Functional
CHEMBL665773
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Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.45 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354788 | — | — | 1 | 6.70 |
| CHEMBL447183 | — | — | 1 | 6.05 |
| CHEMBL352659 | — | — | 1 | 5.92 |
| CHEMBL174310 | — | — | 1 | 5.80 |
| CHEMBL7889 | L-NIL | — | 1 | 5.55 |
| CHEMBL354516 | — | — | 1 | 5.40 |
| CHEMBL367556 | — | — | 1 | 5.35 |
| CHEMBL366978 | — | — | 1 | 5.04 |
| CHEMBL174290 | — | — | 1 | 5.02 |
| CHEMBL173505 | — | — | 1 | 4.96 |
| CHEMBL170580 | — | — | 1 | 4.92 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.68 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | - |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | - |
| CHEMBL170176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354788 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL447183 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL352659 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL174310 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL7889 | L-NIL | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL354516 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL367556 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL366978 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL174290 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL173505 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL170580 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL256147 | TILARGININE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL7890 | L-NAME | IC50 | > | 300000.0 | nM | - |
| CHEMBL225304 | PIMAGEDINE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL170176 | — | IC50 | > | 500000.0 | nM | - |