Assay Detail
Binding
CHEMBL665782
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In vitro inhibition of porcine Dipeptidylpeptidase IV.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627326 | — | — | 1 | 8.70 |
| CHEMBL86677 | — | — | 1 | 8.40 |
| CHEMBL86800 | — | — | 1 | 8.15 |
| CHEMBL88949 | — | — | 1 | 8.15 |
| CHEMBL1627303 | — | — | 1 | 8.10 |
| CHEMBL89666 | — | — | 1 | 8.10 |
| CHEMBL312855 | — | — | 1 | 7.96 |
| CHEMBL313498 | — | — | 1 | 7.92 |
| CHEMBL87153 | — | — | 1 | 7.92 |
| CHEMBL86539 | — | — | 1 | 7.85 |
| CHEMBL327435 | — | — | 1 | 7.82 |
| CHEMBL430452 | — | — | 1 | 7.82 |
| CHEMBL315434 | — | — | 1 | 7.60 |
| CHEMBL88680 | — | — | 1 | 7.54 |
| CHEMBL330523 | — | — | 1 | 7.19 |
| CHEMBL328365 | — | — | 1 | 6.97 |
| CHEMBL89272 | — | — | 1 | 6.87 |
| CHEMBL89465 | — | — | 1 | 6.64 |
| CHEMBL86334 | — | — | 1 | 5.79 |
| CHEMBL327781 | — | — | 1 | 5.71 |
| CHEMBL90223 | — | — | 1 | 5.12 |
| CHEMBL89273 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627326 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL86677 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL86800 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL88949 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1627303 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL89666 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL312855 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL313498 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL87153 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL86539 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL327435 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL430452 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL315434 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL88680 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL330523 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL328365 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL89272 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL89465 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL86334 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL327781 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL90223 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL89273 | — | Ki | = | 10000.0 | nM | 5.00 |