Assay Detail
Binding
CHEMBL665836
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Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.42 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174501 | — | — | 1 | 6.54 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 5.54 |
| CHEMBL173009 | — | — | 1 | 5.26 |
| CHEMBL368546 | — | — | 1 | 4.92 |
| CHEMBL178896 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174501 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL316040 | TEPOXALIN | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL173009 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL368546 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL178896 | — | IC50 | = | 14000.0 | nM | 4.85 |