Assay Detail
Binding
CHEMBL665837
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Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.03 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369252 | — | — | 1 | 7.52 |
| CHEMBL173133 | — | — | 1 | 7.22 |
| CHEMBL368682 | — | — | 1 | 7.05 |
| CHEMBL175153 | — | — | 1 | 6.96 |
| CHEMBL435907 | — | — | 1 | 6.80 |
| CHEMBL176844 | — | — | 1 | 6.75 |
| CHEMBL264200 | — | — | 1 | 6.72 |
| CHEMBL177727 | — | — | 1 | 6.66 |
| CHEMBL174976 | — | — | 1 | 6.55 |
| CHEMBL367010 | — | — | 1 | 6.47 |
| CHEMBL174684 | — | — | 1 | 6.31 |
| CHEMBL174922 | — | — | 1 | 6.16 |
| CHEMBL175995 | — | — | 1 | 6.12 |
| CHEMBL368148 | — | — | 1 | 6.03 |
| CHEMBL366595 | — | — | 1 | 5.92 |
| CHEMBL173939 | — | — | 1 | 5.85 |
| CHEMBL353553 | — | — | 1 | 5.80 |
| CHEMBL176945 | — | — | 1 | 5.77 |
| CHEMBL175150 | — | — | 1 | 5.68 |
| CHEMBL174616 | — | — | 1 | 5.54 |
| CHEMBL177462 | — | — | 1 | 5.47 |
| CHEMBL425860 | — | — | 1 | 5.26 |
| CHEMBL369848 | — | — | 1 | 5.21 |
| CHEMBL176200 | — | — | 1 | 5.00 |
| CHEMBL175372 | — | — | 1 | 4.94 |
| CHEMBL176668 | — | — | 1 | 4.84 |
| CHEMBL262539 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369252 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL173133 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL368682 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL175153 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL435907 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL176844 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL264200 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL177727 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL174976 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL367010 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL174684 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL174922 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL175995 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL368148 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL366595 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL173939 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL353553 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL176945 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL175150 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL174616 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL177462 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL425860 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL369848 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL176200 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL175372 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL176668 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL262539 | — | IC50 | = | 70400.0 | nM | 4.15 |