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Assay Detail

CHEMBL665869

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Binding
Antibacterial activity against Staphylococcus aureus
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Dihydrofolate reductase (CHEMBL1681620)
Type SINGLE PROTEIN
Organism Staphylococcus aureus

Publication

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Roth B, Tidwell MY, Ferone R, Baccanari DP, Sigel CW, DeAngelis D, Elwell LP.
J Med Chem (1989) 32 : 1949 -1958
PubMed 2754716 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 8.51 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL59946 1 8.52
CHEMBL26337 1 8.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL59946 Ki = 3.0 nM 8.52
CHEMBL26337 Ki = 3.2 nM 8.49