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Assay Detail

CHEMBL665891

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Cholecystokinin type A receptor
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2798)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists
Kawanishi Y, Ishihara S, Tsushima T, Seno K, Miyagoshi M, Hagishita S, Ishikawa M, Shima N, Shimamura M, Ishihara Y
Bioorg Med Chem Lett (1996) 6 : 1421 -1426
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.87 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30821 1 6.92
CHEMBL281318 1 6.72
CHEMBL265987 1 6.72
CHEMBL30917 1 6.48
CHEMBL262125 1 6.48
CHEMBL279778 1 6.47
CHEMBL280980 1 6.42
CHEMBL286908 1 6.41
CHEMBL278217 1 6.37
CHEMBL30430 1 6.25
CHEMBL29331 1 6.19
CHEMBL286907 1 6.14
CHEMBL281082 1 6.12
CHEMBL31090 1 6.05
CHEMBL30656 1 5.96
CHEMBL286475 1 5.89
CHEMBL285586 1 5.70
CHEMBL31726 1 5.68
CHEMBL31671 1 5.60
CHEMBL30701 1 5.44
CHEMBL284183 1 5.39
CHEMBL285746 1 5.32
CHEMBL33819 1 5.28
CHEMBL29888 1 5.27
CHEMBL30195 1 5.24
CHEMBL281017 1 5.04
CHEMBL282645 1 5.03
CHEMBL9387 L-365260 1 4.96
CHEMBL282646 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30821 IC50 = 120.0 nM 6.92
CHEMBL281318 IC50 = 190.0 nM 6.72
CHEMBL265987 IC50 = 190.0 nM 6.72
CHEMBL30917 IC50 = 330.0 nM 6.48
CHEMBL262125 IC50 = 330.0 nM 6.48
CHEMBL279778 IC50 = 340.0 nM 6.47
CHEMBL280980 IC50 = 380.0 nM 6.42
CHEMBL286908 IC50 = 390.0 nM 6.41
CHEMBL278217 IC50 = 430.0 nM 6.37
CHEMBL30430 IC50 = 560.0 nM 6.25
CHEMBL29331 IC50 = 650.0 nM 6.19
CHEMBL286907 IC50 = 720.0 nM 6.14
CHEMBL281082 IC50 = 760.0 nM 6.12
CHEMBL31090 IC50 = 900.0 nM 6.05
CHEMBL30656 IC50 = 1090.0 nM 5.96
CHEMBL286475 IC50 = 1300.0 nM 5.89
CHEMBL285586 IC50 = 2000.0 nM 5.70
CHEMBL31726 IC50 = 2100.0 nM 5.68
CHEMBL31671 IC50 = 2500.0 nM 5.60
CHEMBL30701 IC50 = 3600.0 nM 5.44
CHEMBL284183 IC50 = 4100.0 nM 5.39
CHEMBL285746 IC50 = 4800.0 nM 5.32
CHEMBL33819 IC50 = 5200.0 nM 5.28
CHEMBL29888 IC50 = 5400.0 nM 5.27
CHEMBL30195 IC50 = 5700.0 nM 5.24
CHEMBL281017 IC50 = 9200.0 nM 5.04
CHEMBL282645 IC50 = 9400.0 nM 5.03
CHEMBL9387 L-365260 IC50 = 11100.0 nM 4.96
CHEMBL282646 IC50 = 15000.0 nM 4.82