Assay Detail
Functional
CHEMBL665909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.26 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115454 | — | — | 1 | 5.48 |
| CHEMBL327129 | — | — | 1 | 5.47 |
| CHEMBL114530 | — | — | 1 | 5.44 |
| CHEMBL115274 | — | — | 1 | 5.43 |
| CHEMBL111997 | — | — | 1 | 5.42 |
| CHEMBL114466 | — | — | 1 | 5.41 |
| CHEMBL326627 | — | — | 1 | 5.25 |
| CHEMBL115014 | — | — | 1 | 5.10 |
| CHEMBL325179 | — | — | 1 | 4.96 |
| CHEMBL116169 | — | — | 1 | 4.96 |
| CHEMBL442012 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115454 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL327129 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL114530 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL115274 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL111997 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL114466 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL326627 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL115014 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL325179 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL116169 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL442012 | — | IC50 | = | 13000.0 | nM | 4.89 |