Assay Detail
Functional
CHEMBL665910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.97 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112566 | — | — | 1 | 5.16 |
| CHEMBL326138 | — | — | 1 | 5.10 |
| CHEMBL326063 | — | — | 1 | 5.05 |
| CHEMBL114371 | — | — | 1 | 5.05 |
| CHEMBL114702 | — | — | 1 | 5.00 |
| CHEMBL114650 | — | — | 1 | 5.00 |
| CHEMBL114902 | — | — | 1 | 5.00 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 1 | 4.96 |
| CHEMBL324279 | — | — | 1 | 4.96 |
| CHEMBL115248 | — | — | 1 | 4.96 |
| CHEMBL114214 | — | — | 1 | 4.92 |
| CHEMBL324810 | — | — | 1 | 4.92 |
| CHEMBL114709 | — | — | 1 | 4.89 |
| CHEMBL112593 | — | — | 1 | 4.89 |
| CHEMBL112571 | — | — | 1 | 4.85 |
| CHEMBL115056 | — | — | 1 | 4.82 |
| CHEMBL116561 | — | — | 1 | - |
| CHEMBL114631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112566 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL326138 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL326063 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL114371 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL114702 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL114650 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL114902 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL324279 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL115248 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL114214 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL324810 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL114709 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL112593 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL112571 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL115056 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL116561 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114631 | — | IC50 | - | nM | - |