Assay Detail
Binding
CHEMBL665968
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Inhibition of human cyclin-dependent kinase 1-cyclin B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.39 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.66 |
| CHEMBL337300 | — | — | 1 | 7.60 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.40 |
| CHEMBL323657 | — | — | 1 | 6.22 |
| CHEMBL77217 | — | — | 1 | 6.07 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 5.70 |
| CHEMBL134501 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL337300 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL323657 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL77217 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL134501 | — | IC50 | = | 8400.0 | nM | 5.08 |