Assay Detail
Binding
CHEMBL665972
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Inhibition of Cyclin-dependent kinase 1-cyclin B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.42 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140808 | — | — | 1 | 7.10 |
| CHEMBL143491 | — | — | 1 | 7.04 |
| CHEMBL140373 | — | — | 1 | 6.52 |
| CHEMBL143147 | — | — | 1 | 6.17 |
| CHEMBL142648 | — | — | 1 | 5.99 |
| CHEMBL356603 | — | — | 1 | 5.70 |
| CHEMBL139653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140808 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL143491 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL140373 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL143147 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL142648 | — | IC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL356603 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL139653 | — | IC50 | > | 40000.0 | nM | - |