Assay Detail
Binding
CHEMBL665986
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Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoisomers of ketoconazole: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.63 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328863 | — | — | 1 | 6.87 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 6.82 |
| CHEMBL319160 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328863 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL319160 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 608.0 | nM | 6.22 |