Assay Detail
Binding
CHEMBL666022
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Tested for inhibition of cyclooxygenase (ARBC) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.58 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL410500 | — | — | 1 | 6.05 |
| CHEMBL295829 | OXAMETACIN | 2.0 | 1 | 5.96 |
| CHEMBL296543 | — | — | 1 | 5.62 |
| CHEMBL295008 | — | — | 1 | 5.16 |
| CHEMBL295243 | — | — | 1 | 5.15 |
| CHEMBL46871 | — | — | 1 | 4.82 |
| CHEMBL42593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL410500 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL295829 | OXAMETACIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL296543 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL295008 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL295243 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL46871 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL42593 | — | IC50 | > | 20000.0 | nM | - |