Assay Detail
Binding
CHEMBL666044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Corticotropin releasing factor receptor (CHEMBL2111360) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.42 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97340 | — | — | 1 | 9.30 |
| CHEMBL100157 | — | — | 1 | 9.22 |
| CHEMBL328163 | — | — | 1 | 9.15 |
| CHEMBL316624 | — | — | 1 | 9.15 |
| CHEMBL431287 | — | — | 1 | 9.15 |
| CHEMBL328851 | — | — | 1 | 9.10 |
| CHEMBL99286 | — | — | 1 | 8.96 |
| CHEMBL99151 | — | — | 1 | 8.80 |
| CHEMBL420442 | — | — | 1 | 8.74 |
| CHEMBL316470 | — | — | 1 | 8.72 |
| CHEMBL98093 | — | — | 1 | 8.70 |
| CHEMBL99239 | — | — | 1 | 8.68 |
| CHEMBL318051 | — | — | 1 | 8.48 |
| CHEMBL100330 | — | — | 1 | 8.18 |
| CHEMBL99098 | — | — | 1 | 8.12 |
| CHEMBL95265 | — | — | 1 | 8.04 |
| CHEMBL99093 | — | — | 1 | 8.00 |
| CHEMBL319945 | — | — | 1 | 7.77 |
| CHEMBL431810 | — | — | 1 | 6.22 |
| CHEMBL99146 | — | — | 1 | 5.98 |
| CHEMBL99097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97340 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL100157 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL328163 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL316624 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL431287 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL328851 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL99286 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL99151 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL420442 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL316470 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL98093 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL99239 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL318051 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL100330 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL99098 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL95265 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL99093 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL319945 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL431810 | — | Ki | = | 602.0 | nM | 6.22 |
| CHEMBL99146 | — | Ki | = | 1045.0 | nM | 5.98 |
| CHEMBL99097 | — | Ki | > | 10000.0 | nM | - |