Assay Detail
Binding
CHEMBL666049
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In vitro binding affinity to the CRF receptor in rat cortical homogenates
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Corticotropin releasing factor receptor (CHEMBL2111360) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.64 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23959 | — | — | 1 | 9.70 |
| CHEMBL430913 | — | — | 1 | 9.40 |
| CHEMBL23342 | — | — | 1 | 9.30 |
| CHEMBL22622 | — | — | 1 | 9.22 |
| CHEMBL3085294 | — | — | 1 | 9.22 |
| CHEMBL23439 | — | — | 1 | 9.15 |
| CHEMBL431105 | — | — | 1 | 9.13 |
| CHEMBL22433 | — | — | 1 | 9.10 |
| CHEMBL23354 | — | — | 1 | 9.00 |
| CHEMBL423475 | — | — | 1 | 9.00 |
| CHEMBL23483 | — | — | 1 | 9.00 |
| CHEMBL276971 | — | — | 1 | 8.96 |
| CHEMBL23950 | — | — | 1 | 8.89 |
| CHEMBL282289 | — | — | 1 | 8.85 |
| CHEMBL23291 | — | — | 1 | 8.82 |
| CHEMBL22213 | — | — | 1 | 8.74 |
| CHEMBL280666 | — | — | 1 | 8.72 |
| CHEMBL431886 | — | — | 1 | 8.64 |
| CHEMBL23105 | — | — | 1 | 8.62 |
| CHEMBL23178 | — | — | 1 | 8.62 |
| CHEMBL23669 | — | — | 1 | 8.46 |
| CHEMBL23630 | — | — | 1 | 8.33 |
| CHEMBL279734 | — | — | 1 | 8.29 |
| CHEMBL23898 | — | — | 1 | 8.17 |
| CHEMBL23788 | — | — | 1 | 7.80 |
| CHEMBL23112 | — | — | 1 | 7.68 |
| CHEMBL444011 | — | — | 1 | 7.62 |
| CHEMBL280665 | — | — | 1 | 7.08 |
| CHEMBL23799 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23959 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL430913 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL23342 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL22622 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3085294 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL23439 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL431105 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL22433 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL23354 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL423475 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL23483 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL276971 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL23950 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL282289 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL23291 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL22213 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL280666 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL431886 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL23105 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL23178 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL23669 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL23630 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL279734 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL23898 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL23788 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL23112 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL444011 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL280665 | — | Ki | = | 82.7 | nM | 7.08 |
| CHEMBL23799 | — | Ki | = | 95.6 | nM | 7.02 |