Assay Detail
Binding
CHEMBL666051
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In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Corticotropin releasing factor receptor (CHEMBL2111360) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.40 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22213 | — | — | 1 | 8.74 |
| CHEMBL25256 | — | — | 1 | 8.72 |
| CHEMBL422223 | — | — | 1 | 8.64 |
| CHEMBL26610 | — | — | 1 | 8.55 |
| CHEMBL24803 | — | — | 1 | 8.54 |
| CHEMBL285666 | — | — | 1 | 8.52 |
| CHEMBL26347 | — | — | 1 | 8.46 |
| CHEMBL26346 | — | — | 1 | 8.36 |
| CHEMBL279954 | — | — | 1 | 8.27 |
| CHEMBL280722 | — | — | 1 | 8.05 |
| CHEMBL25132 | — | — | 1 | 8.04 |
| CHEMBL24666 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22213 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL25256 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL422223 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL26610 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL24803 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL285666 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL26347 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL26346 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL279954 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL280722 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL25132 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL24666 | — | Ki | = | 14.0 | nM | 7.85 |