Assay Detail
Binding
CHEMBL666114
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Inhibition of Cyclin-dependent kinase 4-cyclin D
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D (CHEMBL2095942) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.99 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430653 | — | — | 1 | 8.05 |
| CHEMBL317953 | — | — | 1 | 7.58 |
| CHEMBL328406 | — | — | 1 | 7.52 |
| CHEMBL318564 | — | — | 1 | 7.11 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.00 |
| CHEMBL100012 | — | — | 1 | 6.89 |
| CHEMBL420463 | — | — | 1 | 6.63 |
| CHEMBL295136 | — | — | 1 | 6.16 |
| CHEMBL103714 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430653 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL317953 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL328406 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL318564 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL100012 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL420463 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL295136 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL103714 | — | IC50 | = | 1090.0 | nM | 5.96 |