Assay Detail
Binding
CHEMBL666139
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Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, Pfmrk
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.95 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127798 | — | — | 1 | 5.85 |
| CHEMBL126408 | — | — | 1 | 5.54 |
| CHEMBL363491 | — | — | 1 | 5.51 |
| CHEMBL1213804 | — | — | 1 | 5.46 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.40 |
| CHEMBL126602 | — | — | 1 | 5.40 |
| CHEMBL293798 | — | — | 1 | 5.29 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 4.82 |
| CHEMBL130414 | — | — | 1 | 4.77 |
| CHEMBL340874 | — | — | 1 | 4.77 |
| CHEMBL126615 | — | — | 1 | 4.62 |
| CHEMBL23327 | PURVALANOLA | — | 1 | 4.58 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 4.52 |
| CHEMBL340803 | — | — | 1 | 4.38 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 4.29 |
| CHEMBL1242973 | BUTYROLACTONE I | — | 1 | 4.03 |
| CHEMBL338203 | — | — | 1 | - |
| CHEMBL127907 | — | — | 1 | - |
| CHEMBL127205 | — | — | 1 | - |
| CHEMBL338983 | — | — | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
| CHEMBL103307 | — | — | 1 | - |
| CHEMBL127506 | — | — | 1 | - |
| CHEMBL126652 | — | — | 1 | - |
| CHEMBL337993 | — | — | 1 | - |
| CHEMBL127819 | — | — | 1 | - |
| CHEMBL280074 | OLOMOUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127798 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL126408 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL363491 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1213804 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL126602 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL293798 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL130414 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL340874 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL126615 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL23327 | PURVALANOLA | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL340803 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1242973 | BUTYROLACTONE I | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL338203 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL127907 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL127205 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL338983 | — | IC50 | > | 21000.0 | nM | - |
| CHEMBL14762 | SELICICLIB | IC50 | > | 1000000.0 | nM | - |
| CHEMBL103307 | — | IC50 | > | 42000.0 | nM | - |
| CHEMBL127506 | — | IC50 | > | 44000.0 | nM | - |
| CHEMBL126652 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL337993 | — | IC50 | > | 4300.0 | nM | - |
| CHEMBL127819 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL280074 | OLOMOUCINE | IC50 | > | 1000000.0 | nM | - |