Assay Detail
Binding
CHEMBL666143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cyclin-dependent kinase 1 cyclin B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.63 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213804 | — | — | 1 | 4.92 |
| CHEMBL127798 | — | — | 1 | 4.54 |
| CHEMBL126408 | — | — | 1 | 4.54 |
| CHEMBL363491 | — | — | 1 | 4.52 |
| CHEMBL126602 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213804 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL127798 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL126408 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL363491 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL126602 | — | IC50 | > | 16000.0 | nM | - |