Assay Detail
ADMET
CHEMBL666159
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Concentration required to inhibit cytochrome P450 1A2.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.69 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112532 | — | — | 1 | 8.15 |
| CHEMBL150799 | — | — | 1 | 6.92 |
| CHEMBL345544 | — | — | 1 | 6.55 |
| CHEMBL151207 | — | — | 1 | 6.41 |
| CHEMBL267865 | — | — | 1 | 6.34 |
| CHEMBL150653 | — | — | 1 | 6.31 |
| CHEMBL151449 | — | — | 1 | 6.24 |
| CHEMBL151170 | — | — | 1 | 5.96 |
| CHEMBL151354 | — | — | 1 | 5.90 |
| CHEMBL433737 | — | — | 1 | 5.59 |
| CHEMBL150681 | — | — | 1 | 5.49 |
| CHEMBL149750 | — | — | 1 | 5.25 |
| CHEMBL359116 | — | — | 1 | 5.23 |
| CHEMBL358214 | — | — | 1 | 5.09 |
| CHEMBL347303 | — | — | 1 | 5.06 |
| CHEMBL348263 | — | — | 1 | 5.00 |
| CHEMBL422858 | — | — | 1 | 4.85 |
| CHEMBL356594 | — | — | 1 | 4.68 |
| CHEMBL150999 | — | — | 1 | 4.59 |
| CHEMBL151037 | — | — | 1 | 4.16 |
| CHEMBL151038 | — | — | 1 | - |
| CHEMBL150146 | — | — | 1 | - |
| CHEMBL358880 | — | — | 1 | - |
| CHEMBL151974 | — | — | 1 | - |
| CHEMBL150278 | — | — | 1 | - |
| CHEMBL358216 | — | — | 1 | - |
| CHEMBL151280 | — | — | 1 | - |
| CHEMBL434317 | — | — | 1 | - |
| CHEMBL151646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112532 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL150799 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL345544 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL151207 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL267865 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL150653 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL151449 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL151170 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL151354 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL433737 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL150681 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL149750 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL359116 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL358214 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL347303 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL348263 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL422858 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL356594 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL150999 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL151037 | — | IC50 | = | 69900.0 | nM | 4.16 |
| CHEMBL151038 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL150146 | — | IC50 | > | 46.0 | nM | - |
| CHEMBL358880 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151974 | — | IC50 | > | 46.0 | nM | - |
| CHEMBL150278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358216 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151280 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL434317 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151646 | — | IC50 | < | 46.0 | nM | - |