Assay Detail
Binding
CHEMBL666236
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Inhibitory activity against dihydrofolate reductase of rat liver
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of dihydrofolate reductase: structure-activity correlations of quinazolines based upon molecular shape analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.66 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268584 | — | — | 1 | 8.40 |
| CHEMBL7049 | — | — | 1 | 8.38 |
| CHEMBL7403 | — | — | 1 | 8.30 |
| CHEMBL7176 | — | — | 1 | 8.30 |
| CHEMBL6979 | — | — | 1 | 8.15 |
| CHEMBL157652 | — | — | 1 | 8.15 |
| CHEMBL355093 | — | — | 1 | 8.12 |
| CHEMBL6975 | — | — | 1 | 8.00 |
| CHEMBL6877 | — | — | 1 | 7.96 |
| CHEMBL6841 | — | — | 1 | 7.89 |
| CHEMBL6812 | — | — | 1 | 7.77 |
| CHEMBL414017 | — | — | 1 | 7.74 |
| CHEMBL7134 | — | — | 1 | 7.70 |
| CHEMBL266875 | — | — | 1 | 7.70 |
| CHEMBL268310 | — | — | 1 | 7.64 |
| CHEMBL266761 | — | — | 1 | 7.62 |
| CHEMBL6949 | — | — | 1 | 7.48 |
| CHEMBL269235 | — | — | 1 | 7.47 |
| CHEMBL268089 | WR-159412 | — | 1 | 7.44 |
| CHEMBL266638 | — | — | 1 | 7.00 |
| CHEMBL6772 | — | — | 1 | 6.70 |
| CHEMBL427605 | — | — | 1 | 6.70 |
| CHEMBL266320 | — | — | 1 | 6.25 |
| CHEMBL6708 | — | — | 1 | 6.18 |
| CHEMBL7077 | — | — | 1 | 6.09 |
| CHEMBL267617 | — | — | 1 | 5.82 |
| CHEMBL268456 | — | — | 1 | 5.66 |
| CHEMBL6549 | — | — | 1 | 5.60 |
| CHEMBL6823 | — | — | 1 | 5.52 |
| CHEMBL267002 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268584 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL7049 | — | IC50 | = | 4.169 | nM | 8.38 |
| CHEMBL7176 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL7403 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL6979 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL157652 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL355093 | — | IC50 | = | 7.586 | nM | 8.12 |
| CHEMBL6975 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL6877 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL6841 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL6812 | — | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL414017 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL7134 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL266875 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL268310 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL266761 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL6949 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL269235 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL268089 | WR-159412 | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL266638 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL427605 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL6772 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL266320 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL6708 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL7077 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL267617 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL268456 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL6549 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL6823 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL267002 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL267928 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL6950 | — | IC50 | = | 9332.54 | nM | 5.03 |
| CHEMBL7275 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL7246 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL6693 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL268354 | — | IC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL6885 | QUINAZOLINE-2,4,6-TRIAMINE | IC50 | = | 26915.35 | nM | 4.57 |
| CHEMBL6642 | — | IC50 | = | 54954.09 | nM | 4.26 |
| CHEMBL6552 | — | IC50 | = | 57543.99 | nM | 4.24 |