Assay Detail
Binding
CHEMBL666355
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Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.69 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87734 | — | — | 1 | 9.31 |
| CHEMBL86931 | — | — | 1 | 8.80 |
| CHEMBL315468 | — | — | 1 | 8.52 |
| CHEMBL314459 | — | — | 1 | 8.27 |
| CHEMBL313304 | — | — | 1 | 7.86 |
| CHEMBL315750 | — | — | 1 | 7.85 |
| CHEMBL85409 | — | — | 1 | 7.52 |
| CHEMBL82899 | — | — | 1 | 7.50 |
| CHEMBL313530 | — | — | 1 | 7.50 |
| CHEMBL415080 | — | — | 1 | 7.28 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.19 |
| CHEMBL85689 | — | — | 1 | 7.05 |
| CHEMBL2115213 | — | — | 1 | 6.78 |
| CHEMBL84983 | — | — | 1 | 6.61 |
| CHEMBL315005 | — | — | 1 | 6.51 |
| CHEMBL86669 | — | — | 1 | 6.48 |
| CHEMBL86576 | — | — | 1 | 6.43 |
| CHEMBL315849 | — | — | 1 | 6.39 |
| CHEMBL87910 | — | — | 1 | 6.35 |
| CHEMBL420604 | — | — | 1 | 6.32 |
| CHEMBL87172 | — | — | 1 | 6.28 |
| CHEMBL420972 | — | — | 1 | 6.15 |
| CHEMBL431220 | — | — | 1 | 6.06 |
| CHEMBL87958 | — | — | 1 | 5.99 |
| CHEMBL419680 | — | — | 1 | 5.81 |
| CHEMBL2114209 | — | — | 1 | 5.75 |
| CHEMBL86325 | — | — | 1 | 5.64 |
| CHEMBL315535 | — | — | 1 | 5.60 |
| CHEMBL87897 | — | — | 1 | 5.58 |
| CHEMBL85552 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87734 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL86931 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL315468 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL314459 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL313304 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL315750 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL85409 | — | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL82899 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL313530 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL415080 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 64.1 | nM | 7.19 |
| CHEMBL85689 | — | Ki | = | 88.7 | nM | 7.05 |
| CHEMBL2115213 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL84983 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL315005 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL86669 | — | Ki | = | 329.0 | nM | 6.48 |
| CHEMBL86576 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL315849 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL87910 | — | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL420604 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL87172 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL420972 | — | Ki | = | 704.0 | nM | 6.15 |
| CHEMBL431220 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL87958 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL419680 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL2114209 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL86325 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL315535 | — | Ki | = | 2510.0 | nM | 5.60 |
| CHEMBL87897 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL85552 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL84557 | — | Ki | = | 3190.0 | nM | 5.50 |
| CHEMBL420788 | — | Ki | = | 4730.0 | nM | 5.33 |
| CHEMBL83080 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL315516 | — | Ki | > | 10000.0 | nM | - |