Assay Detail
Binding
CHEMBL666359
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Binding affinity towards Dopamine receptor D1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.45 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.85 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.62 |
| CHEMBL1743774 | — | — | 1 | 7.19 |
| CHEMBL1743799 | — | — | 1 | 6.97 |
| CHEMBL1743798 | — | — | 1 | 6.74 |
| CHEMBL1743804 | — | — | 1 | 6.34 |
| CHEMBL1743819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1743774 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1743799 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL1743798 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL1743804 | — | Ki | = | 452.0 | nM | 6.34 |
| CHEMBL1743819 | — | Ki | > | 1000.0 | nM | - |