Assay Detail
Binding
CHEMBL666363
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Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.25 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120512 | — | — | 3 | 7.79 |
| CHEMBL42055 | E-FLUPENTIXOL | 2.0 | 1 | 7.42 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.07 |
| CHEMBL333246 | — | — | 1 | 6.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120512 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL120512 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL120512 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL42055 | E-FLUPENTIXOL | Ki | = | 37.8 | nM | 7.42 |
| CHEMBL715 | OLANZAPINE | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL333246 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 353.0 | nM | 6.45 |