Assay Detail
Binding
CHEMBL666364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.31 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.37 |
| CHEMBL292418 | — | — | 1 | 8.63 |
| CHEMBL303993 | — | — | 1 | 8.18 |
| CHEMBL57579 | — | — | 1 | 7.90 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.30 |
| CHEMBL60706 | — | — | 1 | 7.27 |
| CHEMBL65397 | — | — | 1 | 6.85 |
| CHEMBL299056 | — | — | 1 | 6.76 |
| CHEMBL293828 | — | — | 1 | 6.75 |
| CHEMBL293158 | — | — | 1 | 6.36 |
| CHEMBL57988 | — | — | 1 | 6.25 |
| CHEMBL1788322 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL292418 | — | Ki | = | 2.35 | nM | 8.63 |
| CHEMBL303993 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL57579 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL60706 | — | Ki | = | 53.2 | nM | 7.27 |
| CHEMBL65397 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL299056 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL293828 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL293158 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL57988 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL1788322 | — | Ki | = | 743.0 | nM | 6.13 |