Assay Detail
Binding
CHEMBL666399
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Evaluated for its competitive inhibitory activity against Cytochrome P450 19A1 with the use of human placental microsomal preparation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Placenta |
| Subcellular | Microsomal |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.34 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346234 | — | — | 1 | 7.75 |
| CHEMBL336387 | — | — | 1 | 7.44 |
| CHEMBL154104 | — | — | 1 | 7.39 |
| CHEMBL132530 | FORMESTANE | 2.0 | 1 | 7.27 |
| CHEMBL346952 | — | — | 1 | 7.23 |
| CHEMBL154918 | — | — | 1 | 7.19 |
| CHEMBL152237 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346234 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL336387 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL154104 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL132530 | FORMESTANE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL346952 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL154918 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL152237 | — | Ki | = | 73.0 | nM | 7.14 |