Assay Detail
Binding
CHEMBL666409
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Inhibition constant of compound against Lactobacillus casei Dihydrofolate reductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.09 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31924 | — | — | 1 | 9.70 |
| CHEMBL286400 | — | — | 1 | 9.40 |
| CHEMBL31713 | — | — | 1 | 9.22 |
| CHEMBL31887 | — | — | 1 | 9.05 |
| CHEMBL44684 | — | — | 1 | 8.77 |
| CHEMBL45202 | — | — | 1 | 8.39 |
| CHEMBL296525 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31924 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL286400 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL31713 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL31887 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL44684 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL45202 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL296525 | — | Ki | < | 0.01 | nM | - |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.004 | nM | - |