Assay Detail
Binding
CHEMBL666574
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Inhibition of Dipeptidyl Peptidase IV
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of potent and selective dipeptidyl peptidase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 8.70 |
| CHEMBL98408 | — | — | 1 | 6.90 |
| CHEMBL319514 | — | — | 1 | 6.70 |
| CHEMBL503274 | — | — | 1 | 6.66 |
| CHEMBL318401 | — | — | 1 | 5.10 |
| CHEMBL97483 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL98408 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL319514 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL503274 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL318401 | — | Ki | = | 7880.0 | nM | 5.10 |
| CHEMBL97483 | — | Ki | = | 47600.0 | nM | 4.32 |