Assay Detail
Binding
CHEMBL666605
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Inhibitory activity against baculovirus expressed Cyclin dependent kinase 2-cyclinE
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 7.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126997 | — | — | 1 | 8.70 |
| CHEMBL340904 | — | — | 1 | 8.52 |
| CHEMBL300936 | — | — | 1 | 8.52 |
| CHEMBL126549 | — | — | 1 | 8.52 |
| CHEMBL126328 | — | — | 1 | 8.40 |
| CHEMBL126993 | — | — | 1 | 8.30 |
| CHEMBL129396 | — | — | 1 | 8.30 |
| CHEMBL295136 | — | — | 1 | 8.30 |
| CHEMBL126630 | — | — | 1 | 8.30 |
| CHEMBL2111846 | — | — | 1 | 8.22 |
| CHEMBL129471 | — | — | 1 | 8.22 |
| CHEMBL340794 | — | — | 1 | 7.96 |
| CHEMBL263955 | — | — | 1 | 7.77 |
| CHEMBL125401 | — | — | 1 | 7.70 |
| CHEMBL126908 | — | — | 1 | 7.60 |
| CHEMBL48796 | — | — | 1 | 7.58 |
| CHEMBL340012 | — | — | 1 | 7.30 |
| CHEMBL126600 | — | — | 1 | 7.30 |
| CHEMBL2112653 | — | — | 1 | 7.22 |
| CHEMBL420143 | — | — | 1 | 7.05 |
| CHEMBL126782 | — | — | 1 | 6.85 |
| CHEMBL129475 | — | — | 1 | 6.82 |
| CHEMBL127929 | — | — | 1 | 6.77 |
| CHEMBL129716 | — | — | 1 | 6.70 |
| CHEMBL435992 | — | — | 1 | 6.60 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.48 |
| CHEMBL339246 | — | — | 1 | 6.47 |
| CHEMBL125731 | — | — | 1 | 6.46 |
| CHEMBL129555 | — | — | 1 | 6.44 |
| CHEMBL340741 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126997 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL340904 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL126549 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL300936 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL126328 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL126993 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129396 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL295136 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL126630 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2111846 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL129471 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL340794 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL263955 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL125401 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL126908 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL48796 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL340012 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL126600 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2112653 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL420143 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL126782 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL129475 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL127929 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL129716 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL435992 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL339246 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL125731 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL129555 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL340741 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL339070 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL126458 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL129009 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL129107 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL126405 | — | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL129466 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL130020 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL340400 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL340796 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL129763 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL126934 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL338401 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL129532 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL129584 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL341286 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL129563 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL125352 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL129213 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL126459 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL126788 | — | IC50 | > | 1000.0 | nM | - |