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Assay Detail

CHEMBL666607

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK1/cyclin B
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Identification of selective inhibitors of cyclin dependent kinase 4.
Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM.
Bioorg Med Chem Lett (2001) 11 : 2209 -2211
PubMed 11514172 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.02 4.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71233 1 4.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71233 IC50 = 95000.0 nM 4.02