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Assay Detail

CHEMBL666614

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Binding
Inhibition of human Dipeptidylpeptidase II (DPP II)
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Dipeptidyl peptidase 2 (CHEMBL3976) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors.
Senten K, Van Der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K.
J Med Chem (2004) 47 : 2906 -2916
PubMed 15139769 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 8.50 9.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98801 — — 1 9.66
CHEMBL98762 — — 1 9.64
CHEMBL99506 — — 1 9.41
CHEMBL418979 — — 1 9.41
CHEMBL99247 — — 1 9.39
CHEMBL98869 — — 1 9.32
CHEMBL98148 — — 1 9.26
CHEMBL97970 — — 1 9.22
CHEMBL98060 — — 1 9.21
CHEMBL99047 — — 1 9.18
CHEMBL99111 — — 1 9.12
CHEMBL98423 — — 1 9.10
CHEMBL317312 — — 1 9.05
CHEMBL97977 — — 1 8.96
CHEMBL98860 — — 1 8.96
CHEMBL100370 — — 1 8.96
CHEMBL317950 — — 1 8.95
CHEMBL97884 — — 1 8.88
CHEMBL317949 — — 1 8.87
CHEMBL440325 — — 1 8.82
CHEMBL98415 — — 1 8.82
CHEMBL327499 — — 1 8.75
CHEMBL101401 — — 1 8.74
CHEMBL430661 — — 1 8.72
CHEMBL99263 — — 1 8.69
CHEMBL319520 — — 1 8.64
CHEMBL330600 — — 1 8.57
CHEMBL99260 — — 1 8.57
CHEMBL329314 — — 1 8.40
CHEMBL329966 — — 1 8.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98801 — IC50 = 0.22 nM 9.66
CHEMBL98762 — IC50 = 0.23 nM 9.64
CHEMBL418979 — IC50 = 0.39 nM 9.41
CHEMBL99506 — IC50 = 0.39 nM 9.41
CHEMBL99247 — IC50 = 0.41 nM 9.39
CHEMBL98869 — IC50 = 0.48 nM 9.32
CHEMBL98148 — IC50 = 0.55 nM 9.26
CHEMBL97970 — IC50 = 0.6 nM 9.22
CHEMBL98060 — IC50 = 0.62 nM 9.21
CHEMBL99047 — IC50 = 0.66 nM 9.18
CHEMBL99111 — IC50 = 0.75 nM 9.12
CHEMBL98423 — IC50 = 0.8 nM 9.10
CHEMBL317312 — IC50 = 0.9 nM 9.05
CHEMBL100370 — IC50 = 1.1 nM 8.96
CHEMBL98860 — IC50 = 1.1 nM 8.96
CHEMBL97977 — IC50 = 1.1 nM 8.96
CHEMBL317950 — IC50 = 1.13 nM 8.95
CHEMBL97884 — IC50 = 1.31 nM 8.88
CHEMBL317949 — IC50 = 1.34 nM 8.87
CHEMBL440325 — IC50 = 1.5 nM 8.82
CHEMBL98415 — IC50 = 1.5 nM 8.82
CHEMBL327499 — IC50 = 1.77 nM 8.75
CHEMBL101401 — IC50 = 1.8 nM 8.74
CHEMBL430661 — IC50 = 1.91 nM 8.72
CHEMBL99263 — IC50 = 2.03 nM 8.69
CHEMBL319520 — IC50 = 2.3 nM 8.64
CHEMBL330600 — IC50 = 2.7 nM 8.57
CHEMBL99260 — IC50 = 2.7 nM 8.57
CHEMBL329314 — IC50 = 4.0 nM 8.40
CHEMBL329966 — IC50 = 4.2 nM 8.38
CHEMBL418788 — IC50 = 4.6 nM 8.34
CHEMBL319350 — IC50 = 6.5 nM 8.19
CHEMBL101656 — IC50 = 7.4 nM 8.13
CHEMBL318670 — IC50 = 7.4 nM 8.13
CHEMBL100715 — IC50 = 12.5 nM 7.90
CHEMBL318212 — IC50 = 17.0 nM 7.77
CHEMBL98097 — IC50 = 18.6 nM 7.73
CHEMBL316487 — IC50 = 23.5 nM 7.63
CHEMBL320672 — IC50 = 38.0 nM 7.42
CHEMBL99936 — IC50 = 54.7 nM 7.26
CHEMBL328197 — IC50 = 85.0 nM 7.07
CHEMBL415317 — IC50 = 113.0 nM 6.95
CHEMBL93505 — IC50 = 130.0 nM 6.89
CHEMBL319583 — IC50 = 187.0 nM 6.73
CHEMBL98647 — IC50 = 185.0 nM 6.73