Assay Detail
Binding
CHEMBL666696
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Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.32 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305253 | — | — | 1 | 8.48 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.34 |
| CHEMBL69713 | — | — | 1 | 8.33 |
| CHEMBL305177 | — | — | 1 | 8.32 |
| CHEMBL423123 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305253 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL69713 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL305177 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL423123 | — | IC50 | = | 7.2 | nM | 8.14 |