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Assay Detail

CHEMBL666752

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Cholecystokinin type A receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2798)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and pharmacological evaluation of highly potent dual histamine H2 and gastrin receptor antagonists
Kawanishi Y, Ishihara S, Tsushima T, Seno K, Miyagoshi M, Hagishita S, Ishikawa M, Shima N, Shimamura M, Ishihara Y
Bioorg Med Chem Lett (1996) 6 : 1427 -1430
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.52 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL406844 1 6.51
CHEMBL33412 1 6.13
CHEMBL285995 1 5.89
CHEMBL285719 1 5.78
CHEMBL432671 1 5.51
CHEMBL33698 1 5.44
CHEMBL287295 1 5.42
CHEMBL284975 1 5.38
CHEMBL282175 1 5.36
CHEMBL33743 1 5.34
CHEMBL290122 1 5.30
CHEMBL284976 1 5.21
CHEMBL33398 1 5.09
CHEMBL9387 L-365260 1 4.96
CHEMBL286835 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL406844 IC50 = 310.0 nM 6.51
CHEMBL33412 IC50 = 740.0 nM 6.13
CHEMBL285995 IC50 = 1300.0 nM 5.89
CHEMBL285719 IC50 = 1650.0 nM 5.78
CHEMBL432671 IC50 = 3100.0 nM 5.51
CHEMBL33698 IC50 = 3600.0 nM 5.44
CHEMBL287295 IC50 = 3800.0 nM 5.42
CHEMBL284975 IC50 = 4200.0 nM 5.38
CHEMBL282175 IC50 = 4400.0 nM 5.36
CHEMBL33743 IC50 = 4600.0 nM 5.34
CHEMBL290122 IC50 = 5000.0 nM 5.30
CHEMBL284976 IC50 = 6100.0 nM 5.21
CHEMBL33398 IC50 = 8200.0 nM 5.09
CHEMBL9387 L-365260 IC50 = 11100.0 nM 4.96
CHEMBL286835 IC50 > 1000.0 nM -