Assay Detail
Binding
CHEMBL666784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.07 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330977 | — | — | 1 | 8.55 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.57 |
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 6.57 |
| CHEMBL9387 | L-365260 | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330977 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL9506 | DEVAZEPIDE | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL2062154 | CI-988 | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL9387 | L-365260 | Ki | = | 269.15 | nM | 6.57 |