Assay Detail
Functional
CHEMBL666796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Glucocorticoid-induced aromatase activity in human skin fibroblasts
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.90 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.39 |
| CHEMBL99123 | — | — | 1 | 7.25 |
| CHEMBL95644 | — | — | 1 | 6.98 |
| CHEMBL327757 | — | — | 1 | 6.88 |
| CHEMBL419158 | — | — | 1 | 6.86 |
| CHEMBL97206 | — | — | 1 | 6.85 |
| CHEMBL330638 | — | — | 1 | 6.84 |
| CHEMBL99046 | — | — | 1 | 6.79 |
| CHEMBL317578 | — | — | 1 | 6.67 |
| CHEMBL100219 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL99123 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL95644 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL327757 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL419158 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL97206 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL330638 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL99046 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL317578 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL100219 | — | IC50 | = | 314.0 | nM | 6.50 |