Assay Detail
Binding
CHEMBL666945
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Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Lactobacillus casei ATCC 7469
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.46 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.00 |
| CHEMBL3349020 | — | — | 1 | 7.85 |
| CHEMBL9798 | — | — | 1 | 7.66 |
| CHEMBL2051991 | — | — | 2 | 7.60 |
| CHEMBL9824 | — | — | 1 | 7.50 |
| CHEMBL2051989 | — | — | 2 | 7.46 |
| CHEMBL2051990 | — | — | 1 | 7.42 |
| CHEMBL9973 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3349020 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL9798 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2051991 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL9824 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2051989 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2051990 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL9973 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2051991 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2051989 | — | IC50 | = | 120.0 | nM | 6.92 |