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Assay Detail

CHEMBL667036

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Striatum
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL265)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position
Chang WK, Peters M, Fevig VP, Kozlowski JA, Zhou G, Lowe DB, Guzik H, McQuade RD, Duffy R, Coffin VL, Berger JG
Bioorg Med Chem Lett (1992) 2 : 399 -402
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.09 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62 SCH-23390 1 9.52
CHEMBL130328 1 8.70
CHEMBL131054 1 8.68
CHEMBL130851 1 8.48
CHEMBL128649 1 8.43
CHEMBL340855 1 8.29
CHEMBL334728 1 8.24
CHEMBL336532 1 8.12
CHEMBL127843 1 8.06
CHEMBL422796 1 8.00
CHEMBL339342 1 7.89
CHEMBL336610 1 7.64
CHEMBL128917 1 7.62
CHEMBL338237 1 7.48
CHEMBL340006 1 7.34
CHEMBL334650 1 7.00
CHEMBL340324 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62 SCH-23390 Ki = 0.3 nM 9.52
CHEMBL130328 Ki = 2.0 nM 8.70
CHEMBL131054 Ki = 2.1 nM 8.68
CHEMBL130851 Ki = 3.3 nM 8.48
CHEMBL128649 Ki = 3.7 nM 8.43
CHEMBL340855 Ki = 5.1 nM 8.29
CHEMBL334728 Ki = 5.7 nM 8.24
CHEMBL336532 Ki = 7.6 nM 8.12
CHEMBL127843 Ki = 8.7 nM 8.06
CHEMBL422796 Ki = 10.0 nM 8.00
CHEMBL339342 Ki = 13.0 nM 7.89
CHEMBL336610 Ki = 23.0 nM 7.64
CHEMBL128917 Ki = 24.0 nM 7.62
CHEMBL338237 Ki = 33.0 nM 7.48
CHEMBL340006 Ki = 46.0 nM 7.34
CHEMBL334650 Ki = 100.0 nM 7.00
CHEMBL340324 Ki > 1000.0 nM -