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Assay Detail

CHEMBL667041

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Striatum
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL265)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.
Hedberg MH, Jansen JM, Nordvall G, Hjorth S, Unelius L, Johansson AM.
J Med Chem (1996) 39 : 3491 -3502
PubMed 8784447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.03 7.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119455 1 7.69
CHEMBL53 APOMORPHINE 4.0 1 6.63
CHEMBL53510 1 6.42
CHEMBL332178 1 6.41
CHEMBL115524 1 6.11
CHEMBL331005 1 5.99
CHEMBL326159 1 5.33
CHEMBL119577 1 5.03
CHEMBL116367 1 4.62
CHEMBL334116 1 -
CHEMBL119900 1 -
CHEMBL119593 1 -
CHEMBL118771 1 -
CHEMBL332490 1 -
CHEMBL332771 1 -
CHEMBL435779 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119455 Ki = 20.4 nM 7.69
CHEMBL53 APOMORPHINE Ki = 236.0 nM 6.63
CHEMBL53510 Ki = 382.0 nM 6.42
CHEMBL332178 Ki = 393.0 nM 6.41
CHEMBL115524 Ki = 782.0 nM 6.11
CHEMBL331005 Ki = 1030.0 nM 5.99
CHEMBL326159 Ki = 4620.0 nM 5.33
CHEMBL119577 Ki = 9400.0 nM 5.03
CHEMBL116367 Ki = 23800.0 nM 4.62
CHEMBL334116 Ki > 2000.0 nM -
CHEMBL119900 Ki > 2000.0 nM -
CHEMBL119593 Ki > 2000.0 nM -
CHEMBL118771 Ki > 2000.0 nM -
CHEMBL332490 Ki > 5000.0 nM -
CHEMBL332771 Ki > 5000.0 nM -
CHEMBL435779 Ki > 10000.0 nM -