Assay Detail
Binding
CHEMBL667179
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Antibacterial activity against Escherichia coli
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.03 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278345 | — | — | 1 | 9.40 |
| CHEMBL59416 | — | — | 1 | 9.10 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.89 |
| CHEMBL282022 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278345 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL59416 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL282022 | — | Ki | = | 1.8 | nM | 8.74 |