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Assay Detail

CHEMBL667185

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Binding
Negative logarithm of inhibition constant (-log Ki) against Dihydrofolate reductase in Escherichia coli
ChEMBL ↗
73
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Dihydrofolate reductase (CHEMBL1809) ↗
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

Nonlinear quantitative structure-activity relationship for the inhibition of dihydrofolate reductase by pyrimidines.
Hirst JD.
J Med Chem (1996) 39 : 3526 -3532
PubMed 8784450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 73 7.18 8.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117105 — — 1 8.87
CHEMBL331292 — — 1 8.87
CHEMBL119302 — — 1 8.87
CHEMBL118649 — — 1 8.85
CHEMBL323889 — — 1 8.82
CHEMBL117584 — — 1 8.82
CHEMBL119640 — — 1 8.57
CHEMBL119068 — — 1 8.42
CHEMBL118262 — — 1 8.38
CHEMBL117390 — — 1 8.35
CHEMBL332543 — — 1 8.18
CHEMBL119777 — — 1 7.94
CHEMBL333852 — — 1 7.87
CHEMBL118560 — — 1 7.87
CHEMBL118032 — — 1 7.82
CHEMBL118229 — — 1 7.80
CHEMBL119326 — — 1 7.77
CHEMBL326377 — — 1 7.74
CHEMBL117749 — — 1 7.72
CHEMBL333752 — — 1 7.71
CHEMBL119503 — — 1 7.69
CHEMBL118909 — — 1 7.66
CHEMBL118561 — — 1 7.56
CHEMBL333024 — — 1 7.54
CHEMBL115428 — — 1 7.53
CHEMBL119421 — — 1 7.41
CHEMBL331685 — — 1 7.23
CHEMBL118515 — — 1 7.22
CHEMBL117848 — — 1 7.20
CHEMBL326184 — — 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117105 — Ki = 1.349 nM 8.87
CHEMBL119302 — Ki = 1.349 nM 8.87
CHEMBL331292 — Ki = 1.349 nM 8.87
CHEMBL118649 — Ki = 1.413 nM 8.85
CHEMBL323889 — Ki = 1.514 nM 8.82
CHEMBL117584 — Ki = 1.514 nM 8.82
CHEMBL119640 — Ki = 2.692 nM 8.57
CHEMBL119068 — Ki = 3.802 nM 8.42
CHEMBL118262 — Ki = 4.169 nM 8.38
CHEMBL117390 — Ki = 4.467 nM 8.35
CHEMBL332543 — Ki = 6.607 nM 8.18
CHEMBL119777 — Ki = 11.48 nM 7.94
CHEMBL333852 — Ki = 13.49 nM 7.87
CHEMBL118560 — Ki = 13.49 nM 7.87
CHEMBL118032 — Ki = 15.14 nM 7.82
CHEMBL118229 — Ki = 15.85 nM 7.80
CHEMBL119326 — Ki = 16.98 nM 7.77
CHEMBL326377 — Ki = 18.2 nM 7.74
CHEMBL117749 — Ki = 19.05 nM 7.72
CHEMBL333752 — Ki = 19.5 nM 7.71
CHEMBL119503 — Ki = 20.42 nM 7.69
CHEMBL118909 — Ki = 21.88 nM 7.66
CHEMBL118561 — Ki = 27.54 nM 7.56
CHEMBL333024 — Ki = 28.84 nM 7.54
CHEMBL115428 — Ki = 29.51 nM 7.53
CHEMBL119421 — Ki = 38.9 nM 7.41
CHEMBL331685 — Ki = 58.88 nM 7.23
CHEMBL118515 — Ki = 60.26 nM 7.22
CHEMBL117848 — Ki = 63.1 nM 7.20
CHEMBL326184 — Ki = 69.18 nM 7.16
CHEMBL119204 — Ki = 74.13 nM 7.13
CHEMBL331415 — Ki = 91.2 nM 7.04
CHEMBL119206 — Ki = 95.5 nM 7.02
CHEMBL325482 — Ki = 102.33 nM 6.99
CHEMBL119762 — Ki = 107.15 nM 6.97
CHEMBL118751 — Ki = 109.65 nM 6.96
CHEMBL119403 — Ki = 117.49 nM 6.93
CHEMBL333695 — Ki = 117.49 nM 6.93
CHEMBL115787 — Ki = 120.23 nM 6.92
CHEMBL119476 — Ki = 128.82 nM 6.89
CHEMBL116376 — Ki = 128.82 nM 6.89
CHEMBL119902 — Ki = 128.82 nM 6.89
CHEMBL122122 — Ki = 138.04 nM 6.86
CHEMBL119583 — Ki = 144.54 nM 6.84
CHEMBL326266 — Ki = 151.36 nM 6.82
CHEMBL120348 — Ki = 151.36 nM 6.82
CHEMBL118414 — Ki = 151.36 nM 6.82
CHEMBL333022 — Ki = 165.96 nM 6.78
CHEMBL116322 — Ki = 199.53 nM 6.70
CHEMBL119101 — Ki = 223.87 nM 6.65