Assay Detail
Binding
CHEMBL667223
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Inhibitory activity against dihydrofolate reductase in rat liver
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 10. 2,4-Diamino-5-(6-quinolylmethyl)- and -[(tetrahydro-6-quinolyl)methyl]pyrimidine derivatives. Further specificity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.54 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58455 | — | — | 1 | 5.24 |
| CHEMBL57900 | — | — | 1 | 5.00 |
| CHEMBL293325 | — | — | 1 | 4.92 |
| CHEMBL441616 | — | — | 1 | 4.82 |
| CHEMBL57459 | — | — | 1 | 4.75 |
| CHEMBL294638 | — | — | 1 | 4.70 |
| CHEMBL60632 | — | — | 1 | 4.66 |
| CHEMBL59283 | — | — | 1 | 4.66 |
| CHEMBL58744 | — | — | 1 | 4.50 |
| CHEMBL58038 | — | — | 1 | 4.48 |
| CHEMBL56652 | — | — | 1 | 4.42 |
| CHEMBL60636 | — | — | 1 | 4.39 |
| CHEMBL57377 | — | — | 1 | 4.37 |
| CHEMBL57812 | — | — | 1 | 4.36 |
| CHEMBL57458 | — | — | 1 | 4.36 |
| CHEMBL57807 | — | — | 1 | 4.21 |
| CHEMBL293977 | — | — | 1 | 4.19 |
| CHEMBL301628 | — | — | 1 | 4.12 |
| CHEMBL60582 | — | — | 1 | 4.05 |
| CHEMBL59491 | — | — | 1 | - |
| CHEMBL58074 | — | — | 1 | - |
| CHEMBL292839 | — | — | 1 | - |
| CHEMBL292621 | — | — | 1 | - |
| CHEMBL61260 | — | — | 1 | - |
| CHEMBL58917 | — | — | 1 | - |
| CHEMBL57829 | — | — | 1 | - |
| CHEMBL58075 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58455 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL57900 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL293325 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL441616 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL57459 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL294638 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL60632 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL59283 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL58744 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL58038 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL56652 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL60636 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL57377 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL57812 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL57458 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL57807 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL293977 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL301628 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL60582 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL59491 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL58074 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL292839 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL292621 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL61260 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL58917 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL57829 | — | IC50 | = | 440000.0 | nM | - |
| CHEMBL58075 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 340000.0 | nM | - |