Assay Detail
Binding
CHEMBL667225
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Inhibitory activity against Dihydrofolate reductase in rat liver
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.40 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294638 | — | — | 1 | 4.70 |
| CHEMBL58038 | — | — | 1 | 4.48 |
| CHEMBL60827 | — | — | 1 | 4.46 |
| CHEMBL292827 | — | — | 1 | 4.25 |
| CHEMBL294678 | — | — | 1 | 4.12 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL58138 | — | — | 1 | - |
| CHEMBL418293 | — | — | 1 | - |
| CHEMBL60931 | — | — | 1 | - |
| CHEMBL58149 | — | — | 1 | - |
| CHEMBL58079 | — | — | 1 | - |
| CHEMBL300371 | — | — | 1 | - |
| CHEMBL300385 | — | — | 1 | - |
| CHEMBL300545 | — | — | 1 | - |
| CHEMBL418492 | — | — | 1 | - |
| CHEMBL61305 | — | — | 1 | - |
| CHEMBL300370 | — | — | 1 | - |
| CHEMBL60647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294638 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL58038 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL60827 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL292827 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL294678 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 0.0026 | nM | - |
| CHEMBL58138 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL418293 | — | IC50 | = | 233000.0 | nM | - |
| CHEMBL60931 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL58149 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL58079 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL300371 | — | IC50 | = | 174000.0 | nM | - |
| CHEMBL300385 | — | IC50 | = | 340000.0 | nM | - |
| CHEMBL300545 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL418492 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL61305 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL300370 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL60647 | — | IC50 | = | 430000.0 | nM | - |