Assay Detail
Binding
CHEMBL667232
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Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.97 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175747 | — | — | 1 | 6.09 |
| CHEMBL175017 | — | — | 1 | 5.76 |
| CHEMBL369645 | — | — | 1 | 5.75 |
| CHEMBL426584 | — | — | 1 | 5.74 |
| CHEMBL367308 | — | — | 1 | 5.59 |
| CHEMBL426768 | — | — | 1 | 5.58 |
| CHEMBL177408 | — | — | 1 | 5.55 |
| CHEMBL174633 | — | — | 1 | 5.47 |
| CHEMBL175752 | — | — | 1 | 5.45 |
| CHEMBL176848 | — | — | 1 | 5.44 |
| CHEMBL368759 | — | — | 1 | 5.35 |
| CHEMBL367220 | — | — | 1 | 5.34 |
| CHEMBL175577 | — | — | 1 | 5.34 |
| CHEMBL177796 | — | — | 1 | 5.23 |
| CHEMBL367882 | — | — | 1 | 5.22 |
| CHEMBL425506 | — | — | 1 | 5.14 |
| CHEMBL180585 | — | — | 1 | 5.00 |
| CHEMBL176882 | — | — | 1 | 4.89 |
| CHEMBL174954 | — | — | 1 | 4.80 |
| CHEMBL368735 | — | — | 1 | 4.62 |
| CHEMBL366989 | — | — | 1 | 4.53 |
| CHEMBL174617 | — | — | 1 | 4.41 |
| CHEMBL361101 | — | — | 1 | 4.40 |
| CHEMBL174753 | — | — | 1 | 4.30 |
| CHEMBL362254 | — | — | 1 | 4.25 |
| CHEMBL435553 | — | — | 1 | 4.24 |
| CHEMBL368065 | — | — | 1 | 4.23 |
| CHEMBL177125 | — | — | 1 | 4.21 |
| CHEMBL177862 | — | — | 1 | 4.15 |
| CHEMBL369501 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175747 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL175017 | — | IC50 | = | 1724.0 | nM | 5.76 |
| CHEMBL369645 | — | IC50 | = | 1763.0 | nM | 5.75 |
| CHEMBL426584 | — | IC50 | = | 1814.0 | nM | 5.74 |
| CHEMBL367308 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL426768 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL177408 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL174633 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL175752 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL176848 | — | IC50 | = | 3644.0 | nM | 5.44 |
| CHEMBL368759 | — | IC50 | = | 4426.0 | nM | 5.35 |
| CHEMBL367220 | — | IC50 | = | 4527.0 | nM | 5.34 |
| CHEMBL175577 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL177796 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL367882 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL425506 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL180585 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL176882 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL174954 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL368735 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL366989 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL174617 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL361101 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL174753 | — | IC50 | = | 49800.0 | nM | 4.30 |
| CHEMBL362254 | — | IC50 | = | 56750.0 | nM | 4.25 |
| CHEMBL435553 | — | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL368065 | — | IC50 | = | 58350.0 | nM | 4.23 |
| CHEMBL177125 | — | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL177862 | — | IC50 | = | 71300.0 | nM | 4.15 |
| CHEMBL369501 | — | IC50 | = | 71530.0 | nM | 4.15 |
| CHEMBL174679 | — | IC50 | = | 99700.0 | nM | 4.00 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 190000.0 | nM | - |
| CHEMBL369237 | — | IC50 | = | 146200.0 | nM | - |
| CHEMBL177819 | — | IC50 | = | 315300.0 | nM | - |
| CHEMBL177230 | — | IC50 | = | 133100.0 | nM | - |
| CHEMBL362208 | — | IC50 | = | 130600.0 | nM | - |
| CHEMBL174223 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL426950 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL177511 | — | IC50 | = | 197300.0 | nM | - |
| CHEMBL425152 | — | IC50 | = | 110600.0 | nM | - |
| CHEMBL265493 | — | IC50 | = | 115300.0 | nM | - |