Assay Detail
Functional
CHEMBL667339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Beta2-receptor selectivity in canine lung tissue in anesthetized dogs
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98975 | — | — | 1 | 6.55 |
| CHEMBL421005 | — | — | 1 | 6.29 |
| CHEMBL95457 | — | — | 1 | 5.35 |
| CHEMBL316868 | — | — | 1 | 5.24 |
| CHEMBL1192069 | — | — | 1 | 4.39 |
| CHEMBL1193886 | ERSENTILIDE | 2.0 | 2 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98975 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL421005 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL95457 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL316868 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1192069 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1193886 | ERSENTILIDE | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL1193886 | ERSENTILIDE | IC50 | = | 50000.0 | nM | 4.30 |