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Compound Detail

CHEMBL98975

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OC(CNCCOc1ccc(-n2ccnc2)cc1)COc1ccccc1

Basic Information

ChEMBL ID CHEMBL98975
Phase Preclinical
Structure Type MOL
InChI Key XMLOXOFMPHIHFN-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

353.4
MW (Da)
2.28
ALogP
6
HBA
2
HBD
68.5
PSA (Ų)
0.55
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H23N3O3
MW 353.42
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.37

Activity Summary

IC50 3 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor beta
CHEMBL2094118
IC50 7.4 7.4 40.0 1
Beta-1 adrenergic receptor
CHEMBL213
IC50 7.4 7.4 40.0 1
Beta-2 adrenergic receptor
CHEMBL2289
IC50 6.55 6.55 280.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1976812 10.1021/jm00172a033 Canis familiaris 3
1976812 10.1021/jm00172a033 Adrenergic receptor beta 1
1976812 10.1021/jm00172a033 Beta-1 adrenergic receptor 1
1976812 10.1021/jm00172a033 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine