Assay Detail
Functional
CHEMBL667337
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Tested for beta-receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized dogs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Cardiac ventricle |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98975 | — | — | 1 | 7.40 |
| CHEMBL421005 | — | — | 1 | 7.05 |
| CHEMBL95457 | — | — | 1 | 6.57 |
| CHEMBL99718 | — | — | 1 | 6.52 |
| CHEMBL316868 | — | — | 1 | 5.44 |
| CHEMBL320445 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98975 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL421005 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL95457 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL99718 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL316868 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL320445 | — | IC50 | = | 3700.0 | nM | 5.43 |