Assay Detail
Binding
CHEMBL667605
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Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Neisseria gonorrhoeae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 10. 2,4-Diamino-5-(6-quinolylmethyl)- and -[(tetrahydro-6-quinolyl)methyl]pyrimidine derivatives. Further specificity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.21 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57807 | — | — | 1 | 6.80 |
| CHEMBL60636 | — | — | 1 | 6.62 |
| CHEMBL57458 | — | — | 1 | 6.52 |
| CHEMBL60632 | — | — | 1 | 6.40 |
| CHEMBL293977 | — | — | 1 | 6.39 |
| CHEMBL301628 | — | — | 1 | 6.29 |
| CHEMBL61260 | — | — | 1 | 6.28 |
| CHEMBL58074 | — | — | 1 | 6.21 |
| CHEMBL292839 | — | — | 1 | 6.20 |
| CHEMBL56652 | — | — | 1 | 6.16 |
| CHEMBL59491 | — | — | 1 | 6.05 |
| CHEMBL60582 | — | — | 1 | 6.02 |
| CHEMBL58075 | — | — | 1 | 5.85 |
| CHEMBL292621 | — | — | 1 | 5.72 |
| CHEMBL57829 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57807 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL60636 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57458 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL60632 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL293977 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL301628 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL61260 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL58074 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL292839 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL56652 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL59491 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL60582 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL58075 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL292621 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL57829 | — | IC50 | = | 2600.0 | nM | 5.58 |