Assay Detail
Binding
CHEMBL667768
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Tested for inhibitory activity against dihydrofolate reductase in Beef liver
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.81 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104770 | — | — | 1 | 6.70 |
| CHEMBL108006 | — | — | 1 | 6.40 |
| CHEMBL320811 | — | — | 1 | 6.19 |
| CHEMBL104555 | — | — | 1 | 6.19 |
| CHEMBL107167 | — | — | 1 | 5.34 |
| CHEMBL107079 | — | — | 1 | 5.11 |
| CHEMBL321826 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104770 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL108006 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL320811 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL104555 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL107167 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL107079 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL321826 | — | IC50 | = | 19000.0 | nM | 4.72 |