Assay Detail
Binding
CHEMBL667808
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Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23532 | — | — | 1 | 7.66 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.57 |
| CHEMBL23021 | — | — | 1 | 7.41 |
| CHEMBL283518 | — | — | 1 | 7.08 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.99 |
| CHEMBL50514 | — | — | 1 | 6.70 |
| CHEMBL53693 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23532 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL23021 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL283518 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL50514 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL53693 | — | IC50 | = | 210.0 | nM | 6.68 |