Assay Detail
Binding
CHEMBL667812
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Ability to inhibit Lactobacillus casei dihydrofolate reductase in vitro was determined
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.21 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.02 |
| CHEMBL10592 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL10592 | — | IC50 | = | 400.0 | nM | 6.40 |