Assay Detail
Binding
CHEMBL667861
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Binding affinity against Dihydrofolate reductase of rat liver
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.43 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418347 | — | — | 1 | 5.01 |
| CHEMBL13673 | — | — | 1 | 4.57 |
| CHEMBL14001 | — | — | 1 | 4.46 |
| CHEMBL274430 | — | — | 1 | 4.25 |
| CHEMBL14201 | — | — | 1 | 4.16 |
| CHEMBL13820 | — | — | 1 | 4.13 |
| CHEMBL318078 | — | — | 1 | - |
| CHEMBL321942 | — | — | 1 | - |
| CHEMBL13796 | — | — | 1 | - |
| CHEMBL13908 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL320596 | — | — | 1 | - |
| CHEMBL13877 | — | — | 1 | - |
| CHEMBL105006 | — | — | 1 | - |
| CHEMBL14002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418347 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL13673 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL14001 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL274430 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL14201 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL13820 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL318078 | — | IC50 | = | 1100000.0 | nM | - |
| CHEMBL321942 | — | IC50 | = | 640000.0 | nM | - |
| CHEMBL13796 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL13908 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 340000.0 | nM | - |
| CHEMBL320596 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL13877 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL105006 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL14002 | — | IC50 | = | 160000.0 | nM | - |